供biovendor Progranulin Human ELISA 欣博盛供
货号:RMEE103R
名称:Progranulin Human ELISA
规格:96 wells (1 kit)
产品描述:
progranulin也被称为颗粒上皮前体,proepithin或acrogranin。它是一种68.5 kDa蛋白质,由593个氨基酸(包括信号肽)组成,在体内以强糖基化形式出现,因此其大小约为90 kDa。progranulin有七个保守域,由连接序列分离。通过蛋白水解酶分解,在丝氨酸蛋白酶(如弹性蛋白酶)的催化下,产生6-25kDa的大片段,称为颗粒或上皮。progranulin尤其在腺样体组织、脾脏、皮肤上皮、胃肠粘膜、造血细胞和肿瘤细胞等强增殖组织中表达和分泌。到目前为止,还没有一种特定的受体能获得前体蛋白或颗粒的作用。progranulin似乎是一个积极影响伤口愈合的因素。在皮肤损伤的情况下,在癌细胞、巨噬细胞和中性粒细胞中表达增加。progranulin通过激活巨噬细胞和刺激受损组织中的血管生成间接影响伤口愈合。前体蛋白和颗粒的生理作用是相反的。progranulin可抑制TNF介导的促炎过程。另一方面,颗粒似乎刺激促炎细胞因子的分泌。丙戊酸钠对炎症过程的影响也可在动脉硬化斑块中表现出来。在这里,progranulin由平滑肌细胞表达,并影响单核细胞和平滑肌细胞的迁移。在netual系统中,progranulin在小胶质细胞和神经元中表达(在新皮层和海马锥体细胞以及小脑的浦肯野细胞中)。在mRNA水平上,在netual系统infect或损伤时,如I型和IIib型粘多发性脊髓灰质炎、netual系统virus性炎症、肌萎缩性侧索硬化和阿尔茨海默氏症时,可显示出明显的前体蛋白表达增加。除此之外,progranulin似乎与出生前和出生后性别特异性差异的发展以及成人的神经可塑性有关。
特点:
It is suited for Progranulin determination in Serum and Plasma samples
It is extremely sensitive (18 pg/ml) and, thus allows measurements in cell culture media too and in specimens others than serum e.g. in Cerebrospinal fluid, Amnion fluid, Saliva, Urine, Breast milk - is fast: incubation time a total of 2 hours
Single Standards with 75, 250, 750, 1500, 2500 pg/ml human Progranulin are provided in the Kit
2 Control Sera are provided for quality control purposes according GLP
It is calibrated with recombinant Progranulin
Microtiter plates are separately breakapart, tests can be adapted to individual requirements
类型: Sandwich ELISA, Biotin-labelled antibody
别名:Myxovirus resistance protein 1
物种:Human
样本浓度:10 µl/well
校准范围:75–2500 pg/ml
检测限:0.018 ng/ml
应用:Serum, Plasma
运输:At ambient temperature. Upon receipt, store the product at the temperature recommended below.
储存/到期:Store the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).
Biovendor是欧洲的一家生物医药科技公司,其科研及诊断产品事业部成立于1995年。Biovendor公司专注于研发与生产诊断及科研用途的免疫检测试剂盒、抗体以及重组蛋白等产品。
产品覆盖以下研究领域, 主要提供ELISA试剂盒,重组蛋白及相关抗体
凋亡(Apoptosis) |
糖尿病-胰岛素、C-肽、胰岛素原 (Diabetology - Insulin, C-Peptide, Proinsulin) |
肌生长调控 (Muscle Growth Control) |
自身免疫 (Autoimmunity) |
糖尿病-其他相关产品 (Diabetology - Other Relevant Products) |
神经组织标志物 (Neural Tissue Markers) |
血压调节和NO代谢 (Blood Pressure Regulation And NO Metabolism) |
能量代谢和体重调节 (Energy Metabolism And Body Weight Regulation) |
肿瘤学 (Oncology) |
骨与软骨代谢 (Bone And Cartilage Metabolism) |
生长hormone和生长因子相关 (Growth Hormone And Factor-related Products) |
氧化应激 (Oxidative Stress) |
心血管疾病 (Cardiovascular Disease) |
免疫应答、infect和炎症反应 (Immune Response, Infection And Inflammation) |
胰调控分子 (Pancreatic Regulatory Molecules) |
细胞粘连蛋白 (Cell Adhesion Proteins) |
免疫学 (Immunology) |
肾脏疾病 (Renal Disease) |
细胞因子、趋化因子及相关分子 (Cytokines And Chemokines And Related Molecules) |
铁代谢(Iron Metabolism) |
生殖 (Reproduction) |
糖尿病-自身免疫 (Diabetology – Autoimmunity) |
脂蛋白代谢 (Lipoprotein Metabolism) |
细胞表面蛋白 (Cell Surface Proteins (sCD) ) |
分泌型磷脂酶A2 (Secreted Phospholipases A2 show all) |
血清学 (Serology) |
类固醇hormone (Steroid Hormones) |
移植 (Transplantation) |
动物相关研究 (Animal Studies) |
其他研究领域 (Others) |
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