检测认证人脉交流通讯录
供biovendor Fibroblast Growth Factor 21 Mouse/Rat ELISA 欣博盛供
货号：RD291108200R
名称：Fibroblast Growth Factor 21 Mouse/Rat ELISA
规格：96 wells (1 kit)
产品描述：
FGFs是20多个小（约17-26kDa）分泌肽的家族。这些蛋白的最初特征集中在它们刺激成纤维细胞增殖的能力上。这种有丝分裂活性通过FGF受体（FGFRS）1、2或3介导。第四个密切相关的酪氨酸激酶受体（fgfr4）能够结合fgfs，但不会导致有丝分裂反应。 FGFs通过高亲和力FGF受体（fgfrs）的至少5个不同亚家族调节细胞活性：fgfr-1、-2、-3和-4，所有这些亚家族都具有固有的酪氨酸激酶活性，除fgfr-4、多重剪接亚型和fgfr-5外，都缺乏细胞内激酶域。越来越多的证据表明，FGFs对调节葡萄糖和脂质的体内平衡很重要。在β细胞中过度表达显性负性形式的FGFR-1会导致小鼠糖尿病，这意味着正常的β细胞功能和血糖维持需要适当的FGF信号。FGFR-2是胰腺发育过程中的关键分子。此外，FGFR-4与胆固醇代谢和胆汁酸合成有关。研究表明，FGF-19能引起对饮食诱导的肥胖和胰岛素desensitiz的抵抗，并改善糖尿病啮齿类动物的胰岛素、葡萄糖和脂质状况。由于这些影响，至少部分，是通过观察到的代谢率变化介导的，因此，可以将FGF-19视为能量消耗的调节器。 FGF-21在肝脏中优先表达，但对其生物活性及其作用方式的确切认识尚不清楚。FGF-21是脂肪细胞葡萄糖摄取的有效激活剂，在转基因小鼠中过表达时保护动物免受饮食诱导的肥胖，在treatment糖尿病啮齿动物时降低血糖和甘油三酯水平。
特点：
It is intended for research use only
The total assay time is less than 3.5 hours
The kit measures FGF-21 in serum
Assay format is 96 wells
Quality Controls are mouse and rat serum based. No human sera are used
Standard is mouse recombinant protein based
Components of the kit are provided ready to use, concentrated or lyophilized
类型：Sandwich ELISA, Biotin-labelled antibody
别名：FGF-21, UNQ3115/PRO10196
物种：Mouse, Rat
样本浓度：mouse samples: 7 µl/well
rat samples: 50 µl/well校准范围：40–2560 pg/ml
检测限：18.4 pg/ml
应用：Serum
运输：At ambient temperature. Upon receipt, store the product at the temperature recommended below.
储存/到期：Store the complete kit at 2–8°C. Under these conditions, the kit is stable until the expiration date (see label on the box).
交叉反应：
bovine Weak reactivity (recom. dilution 1:3)
cat Yes (recommended dilution 1:3)
dog Non-detectable
goat Yes (recommended dilution 1:6)
hamster Yes (recommended dilution 1:12)
horse Non-detectable
human Non-detectable
pig Yes (recommended dilution 1:3)
rabbit Non-detectable
rat Yes
sheep Yes (recommended dilution 1:3)
chicken Not tested
monkey Non-detectable
mouse Yes
试剂盒组成：
Antibody Coated Microtiter Strips 96 wells
Biotin Labelled Antibody Conc. (10x) 1.3 ml
Streptavidin-HRP Conjugate 13 ml
Master Standard 2 vials
Quality Control MOUSE 2 vials
Quality Control RAT 2 vials
Dilution Buffer 20 ml
Biotin-Ab Diluent 13ml
Wash Solution Conc.(10x) 100 ml
Substrate Solution 13 ml
Stop Solution 13 ml
Product Data Sheet + Certificate of Analysis 1 pc
Biovendor是欧洲的一家生物医药科技公司,其科研及诊断产品事业部成立于1995年。Biovendor公司专注于研发与生产诊断及科研用途的免疫检测试剂盒、抗体以及重组蛋白等产品。
产品覆盖以下研究领域, 主要提供ELISA试剂盒，重组蛋白及相关抗体
凋亡(Apoptosis)
糖尿病-胰岛素、C-肽、胰岛素原
(Diabetology - Insulin, C-Peptide, Proinsulin)
肌生长调控
(Muscle Growth Control)
自身免疫 (Autoimmunity)
糖尿病-其他相关产品
(Diabetology - Other Relevant Products)
神经组织标志物
(Neural Tissue Markers)
血压调节和NO代谢
(Blood Pressure Regulation And NO Metabolism)
能量代谢和体重调节
(Energy Metabolism And Body Weight Regulation)
肿瘤学 (Oncology)
骨与软骨代谢
(Bone And Cartilage Metabolism)
生长hormone和生长因子相关
(Growth Hormone And Factor-related Products)
氧化应激 (Oxidative Stress)
心血管疾病
(Cardiovascular Disease)
免疫应答、infect和炎症反应
(Immune Response, Infection And Inflammation)
胰调控分子
(Pancreatic Regulatory Molecules)
细胞粘连蛋白 (Cell Adhesion Proteins)
免疫学 (Immunology)
肾脏疾病 (Renal Disease)
细胞因子、趋化因子及相关分子
(Cytokines And Chemokines And Related Molecules)
铁代谢(Iron Metabolism)
生殖 (Reproduction)
糖尿病-自身免疫
(Diabetology – Autoimmunity)
脂蛋白代谢
(Lipoprotein Metabolism)
细胞表面蛋白
(Cell Surface Proteins (sCD) )
分泌型磷脂酶A2
(Secreted Phospholipases A2 show all)
血清学 (Serology)
类固醇hormone
(Steroid Hormones)
移植 (Transplantation)
动物相关研究 (Animal Studies)
其他研究领域 (Others)
产品编号
产品名称
规格
检测限
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